Lewy Body Disease

A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Also Known As:

Lewy Body Dementia; Cortical Lewy Body Disease; Lewy Body Disease, Cortical; Lewy Body Disease, Diffuse; Lewy Body Type Senile Dementia; Dementia, Lewy Body; Diffuse Lewy Body Disease

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Synucleinopathies: 2123
    - Lewy Body Disease: 941
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Dementia: 38184
      - Lewy Body Disease: 941
    - Basal Ganglia Diseases: 346
      - Parkinsonian Disorders: 9203
        Lewy Body Disease: 941
  - Movement Disorders: 4634
    - Parkinsonian Disorders: 9203
      - Lewy Body Disease: 941
Mental Disorders: 24177
- Neurocognitive Disorders: 1448
  - Dementia: 38184
    - Lewy Body Disease: 941

National Institute on Aging Selected Research

National Institute on Aging Research Topics

Disease

Drug/Important Bio-Agent (IBA)